Istradefylline forty mg/working day improved peak ranges and AUC of CYP3A4 substrates in medical trials. This impact wasn't observed with istradefylline twenty mg/day. Take into account dose reduction of sensitive CYP3A4 substrates.atazanavir will increase the stage or outcome of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. U